NLR, d-NLR and PLR can be affected by many factors

Distribution List Bas VAN DOORN NLR ( NLR )

NLR-parser: rapid annotation of plant NLR complements

MOTIVATION The repetitive nature of plant disease resistance genes encoding for nucleotide-binding leucine-rich repeat (NLR) proteins hampers their prediction with standard gene annotation software. Motif alignment and search tool (MAST) has previously been reported as a tool to support annotation of NLR-encoding genes. However, the decision if a motif combination represents an NLR protein was ...

Prognostic performance of pre-treatment NLR and PLR in patients suffering from osteosarcoma.

BACKGROUND Inflammatory response markers have been proposed to predict the clinical outcomes in various cancers. The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis of osteosarcoma. METHODS Three hundred fifty-nine patients who underwent curative surgery for osteosarcoma were enrolled from 2005 ...

Genome analysis NLR-parser: rapid annotation of plant NLR complements

Motivation: The repetitive nature of plant disease resistance genes encoding for nucleotidebinding leucine-rich repeat (NLR) proteins hampers their prediction with standard gene annotation software. Motif alignment and search tool (MAST) has previously been reported as a tool to support annotation of NLR-encoding genes. However, the decision if a motif combination represents an NLR protein was ...

Unsolved Mysteries in NLR Biology

NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLRP6, NLRP12, NLRX1). However, NLRP2, NLRP5, and NLRP7 are also involved in non-...